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Clayborne \c-laybor-ne, cla(y)-bo-rne\ as a boy's name is of Old English origin, and the meaning of Clayborne is "brook near a clay-bed, border near a clay-bed". Place name. Clayborne has 7 variant forms: Claiborn, Claiborne, Clay, Claybourne, Clayburn, Klaiborn and Klaibourne. For more information, see also the related name Clayton. Baby names that sound like Clayborne are Clayborn, Claybourn and Claibourne. View a list of the 3 names that reference Clayborne.