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Jefferson \j(e)-ffer-son, jeff(e)-rson\ as a boy's name is of Old English origin, and the meaning of Jefferson is "son of Jeffrey". Surname. Jefferson Davis, born in 1808, was president of the Confederancy. Jefferson has 5 variant forms: Jeff, Jeffers, Jeffersson, Jeffey and Jeffie. For more information, see also the related name Jeffrey. Baby names that sound like Jefferson are Jepherson and Jefferies. View a list of the 6 names that reference Jefferson.