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Holmes \ho(l)-mes\ as a boy's name is pronounced holms. It is of Middle English origin, and the meaning of Holmes is "holly, islands in the river". Arthur Conan Doyle's fictional detective Sherlock Holmes. For more information, see also the related name Hume. Similar baby names are Hermes, Hollis, Holman and Hulme. View a list of the 6 names that reference Holmes.