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Lassie \l(as)-sie\ as a girl's name is of Middle English origin, and the meaning of Lassie is "little girl". "Lass" is a Scottish and Northern English term for a girl. Also the name of an intelligent collie in a popular TV series in the 1960s and 1990s. Lassie has 1 variant form: Lassey. Baby names that sound like Lassie are Lissie and Lyssie.