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Leighton \le(i)-gh-ton\ as a boy's name is pronounced LAY-ton. It is of Old English origin, and the meaning of Leighton is "meadow settlement". Place name used as a first name since the 19th century. Artist Frederick Leighton. Leighton has 2 variant forms: Layton and Leyton. Baby names that sound like Leighton are Litton, Lawton, Lidon, Ledon, Lytton, Littonn and Litten.