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Lysle \l(y)-sle, lys-le\ as a boy's name is a variant of Lisle (English) and Lyle (Old French), and the meaning of Lysle is "the island". The baby name Lysle sounds like Lale, Lyell and Lyall. Other similar baby names are Laslo, Ladle, Leslie, Lesly, Lesley, Leslee, Leslea and Lynley. View a list of the 2 names that reference Lysle.