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Mystique \m(y)-sti-que, mys-tique\ as a girl's name is pronounced miss-TEEK. It is of French origin, and the meaning of Mystique is "air of mystery". Use of Mystique as a contemporary name for girls is probably due to the popularity of the name Misty. Mystique has 2 variant forms: Mystica and Mistique. View a list of the 2 names that reference Mystique.