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Wayne \wa(y)-ne\ as a boy's name is pronounced wayne. It is of Old English origin, and the meaning of Wayne is "wagon builder or driver". Occupational name. Made famous by actor John Wayne. Performer Wayne Newton, hockey player Wayne Gretzky. Wayne has 2 variant forms: Wain and Wayn. Baby names that sound like Wayne are Wynn, Faine, Fane, Wyn, Janne, Vane and Wynne. View a list of the 7 names that reference Wayne.