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Wesley \we(s)-ley\ as a boy's name is pronounced WEZ-lee, WES-lee. It is of Old English origin, and the meaning of Wesley is "western meadow". Place name, variant of the English surname Westley. Used in honor of brothers John and Charles Wesley, 18th-century founders of Methodism, a Protestant Christian denomination. Actors Wesley Snipes, Wes Bentley. Wesley has 5 variant forms: Wes, Wesly, Wessley, Westleigh and Westley. Baby names that sound like Wesley are Asael, Asiel, Wassily, Vasily and Vasile.