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Wye \wye-ye\ as a boy's name is a variant of Wyatt (Old English) and Wylie (Old English), and the meaning of Wye is "war strength, clever, crafty". The baby name Wye sounds like Faye, Fee, Jaye, Jae, Joe and Way. Other similar baby names are Nye, Wyn, Kye, Rye and Tye. View a list of the 2 names that reference Wye.